Tonsillectomy is one of the most common pediatric surgical procedures in the United States.
Postoperative pain is substantial, with typical regimens employing narcotic derivatives and
acetaminophen for 1-2 weeks after surgery. Recent enthusiasm for use of ibuprofen as an
alternative has been tempered by equivocal data on its relative safety in regard to risk of
postoperative hemorrhage. The primary objective is to evaluate efficacy of celecoxib for pain
control after tonsillectomy in children. The secondary objective is to assess safety in
regard to postoperative hemorrhage and adverse events.
Phase:
Phase 2
Details
Lead Sponsor:
Children's Hospital of Philadelphia
Collaborator:
Pfizer
Treatments:
Acetaminophen Acetaminophen, hydrocodone drug combination Calcium Carbonate Celecoxib Oxycodone