Celecoxib Versus Hyoscine Butyl-bromide in Reducing Pain Associated With IUD.

• Status: Completed
• Trial end date: 2018-09-05
• Target enrollment: 0
• Participant gender: Female

Summary

Many oral analgesic drugs such as the nonsteroidal anti-inflammatory drug (NSAID) are used to relieve pain from gynaecological procedures and dysmenorrhea. Hyoscine-N-butyl bromide, an antispasmodic drug is commonly used for relief of smooth muscle spasms and can be used to alleviate genito-urinary spasm. Some studies reported hyoscine couldn't relieve pain in minor gynaecological procedures. So the efficacy of Hyoscine-N-butyl bromide use is still controversial, and no previous studies investigated its effectiveness for pain relief in IUD insertion procedure.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Bromides; Butylscopolammonium Bromide; Celecoxib; Scopolamine; Scopolamine Hydrobromide

Criteria

Inclusion Criteria:

• Non-pregnant nulliparous and parous menstruating women.

• Women who Did not receive any analgesics or misoprostol in the 24 hours prior to insertion.

• Presenting for insertion of CuT380A intrauterine device.

• the absence of contraindication for IUD insertion including positive cultures for gonorrhoea or chlamydia

• the absence of sedative or long-acting narcotics use 48 h before IUD insertion

• No history of severe mental stress in the past two months.

Exclusion Criteria:

• • Allergy to HYOSCINE BUTYLBROMIDE or celecoxib or contraindication to it as paralytic ileus, myasthenia gravis, pyloric stenosis and narrow-angle glaucoma.

• Women who had been pregnant within the previous four weeks.

• Women presenting for IUD removal and reinsertion

• Any uterine abnormalities distorted uterine cavity as congenital anomalies, endometrial lesions, adenomyosis, and submucous myoma.

• Enrollment in another study.

• A psychological or neurological disorder associated with altered pain sensation.

• a history of dysmenorrhea

• a contraindication for IUD use such as a gynaecological malignancy, pelvic inflammatory disease or undiagnosed abnormal vaginal bleeding.