Celecoxib as a Post-tonsillectomy Pain Medication

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The hypothesis is that celecoxib effectively reduces pain after a tonsillectomy and reduces post-operative narcotic use.

To test this hypothesis, the study is placebo controlled (sugar pill). Half of the participants will receive a sugar pill, half will not.

All participants will receive the standard post-operative pain medications.

We ask participants to log the amount of medications they use daily, and the amount of pain they have each day. It is hoped that celecoxib will reduce the amount of post-operative pain medication needed.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Iowa
• Collaborator: Pfizer
• Treatments: Celecoxib

Criteria

Inclusion Criteria:

• Age at least 18 years

• Indication for tonsillectomy (patients undergoing a tonsillectomy as a portion of additional surgical procedures will not be included)

• Have the ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

• History of bleeding disorders

• History of liver or kidney dysfunction

• History of allergy to sulfa containing medications

• History of lactose intolerance

• History of asthma, urticaria, or allergic-type reactions to aspirin or NSAIDs

• Women who are currently pregnant, nursing, or trying to conceive

• History of allergy or intolerance to acetaminophen or hydrocodone

• History of allergy to any COX-2 inhibitor, including celecoxib or rofecoxib.

• PT, PTT, hemoglobin, or hematocrit values that are outside of institutional limits.

• History of cardiovascular disease

• Patients currently taking celecoxib