Celecoxib in Postoperative Analgesia for Radius Fracture Surgery

• Status: Recruiting
• Trial end date: 2023-09-30
• Target enrollment: 0
• Participant gender: All

Summary

Patients scheduled for elective osteosynthesis of the distal radius will be randomized to receive celecoxib 100 mg orally (PO) at 6 in the morning before surgery and every 12 hours for 2 days thereafter, or a placebo pill in the same regimen. After surgery under general anaesthesia, they will receive paracetamol 1 g intravenously (IV) every 6 hours and if pain intensity is greater than 4 on a numeric rating scale (NRS) of 0-10, piritramid 15 mg intramuscularly (IM) will be administered. Pain intensity, piritramid consumption and side effects of treatment will be recorded in a questionnaire for 2 days.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Charles University, Czech Republic
• Collaborator: Faculty Hospital Kralovske Vinohrady
• Treatments: Celecoxib

Criteria

Inclusion Criteria:

• Patients scheduled for osteosynthesis of distal radius fracture

Exclusion Criteria:

• Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to celecoxib

• History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.

• Patients who have demonstrated allergic-type reactions to sulfonamides.

• Inability to understand the questionnaire