Celiprolol Versus Ditiazem for the Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery

• Status: Unknown status
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Cardiac arrythmias are the most common cardiac complications after thoracic surgery. They are made primarily of postoperative atrial fibrillation (POAF).

They are associated with an increased risk of stroke, increased length of hospital stay and cost of care, and increased long-term mortality.

Randomized , single-blind prospective study in the anesthesia and intensive care department of Abderrahmen Mami hospital Ariana Tunisia comparing the efficacy of Diltiazem versus Celiprolol in the prevention of postoperative cardiac arrythmias in patients proposed for pneumonectomy and bilobectomy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Abderrahmane Mami Hospital
• Treatments: Celiprolol; Diltiazem

Criteria

Inclusion Criteria:

• Age ≥ 18 years Sinus rhythm preoperatively.

Surgery at high risk of atrial arrhythmia occurring postoperatively:

• Bi-lobectomy

• Pneumonectomie

Exclusion Criteria:

• Signs of myocardial ischemia per or post operative.

• Persistent postoperative hypotension requiring the use of catecholamines.

• Persistent bradycardia

• Decompensated cardiac insufficiency.

• Acute intestinal obstruction.