Celiprolol in Patients With Ehlers-Danlos Syndrome, Vascular Type

• Status: Completed
• Trial end date: 2011-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Ehlers-Danlos syndrome vascular type (EDS-IV) is caused by a genetic defect of collagen type III. Patient die (median 40 yrs) of vascular complications. There is no treatment. We showed that arteries are thin and overloaded in this patients. We test the protective effect of celiprolol on cardiovascular events in a 5 years, randomized, PROBE design

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Collaborator: Aventis Pharmaceuticals
• Treatments: Celiprolol

Criteria

Inclusion Criteria:

• Proven disease,

• No betablocker at inclusion if previous CV event

Exclusion criteria:

Criteria of not inclusion for the RIGHTEOUS group:

• Patient having already presented an arterial break or a dissection and treated(handled) by bétâ-blocking(surrounding).

• Against indication in the use of CELIPROLOL:

• Unchecked cardiac insufficiency by the treatment

• cardiogenic shock

• BAV of 2nd and 3rd not sailed degrees

• angor of Prinzmetal

• disease of the sine

• bradycardia

• pheochromocytoma untreated

• low blood pressure

• sentimentality in the CELIPROLOL

• Antecedent of anaphylactic reaction

• myasthenia

• treatment by FLOCTAFENINE ( Idarac), Sultopride ( interactions ) In these two cases, the patient can be included in the group followed by troop.

Criteria of not inclusion for both groups:

• Refusal to participate in the study.

• Impossibility to move.

• Pregnancy

• Woman in age to procreate without means of effective contraception.