Cellulitis Optimal Antibiotic Treatment

• Status: Not yet recruiting
• Trial end date: 2025-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine whether a short course of oral flucloxacillin (5 days) is non-inferior to a standard course (7 days) in terms of pain over days 6-14 (indicative of persistence or recurrence associated with the symptoms of most importance to patients) in adults with cellulitis of the leg presenting in primary care.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Southampton
• Collaborators: Norfolk and Norwich University Hospitals NHS Foundation Trust; University Hospital Southampton NHS Foundation Trust; University of East Anglia; University of Nottingham
• Treatments: Floxacillin

Criteria

Inclusion Criteria:

• Must be aged 18 years or older

• Currently showing symptoms of cellulitis (such as pain, tenderness, redness, other change in skin color, warmth to touch) in one leg for 10 days or less

• Pain rated as 3/10 or higher on a numerical rating scale (0-10) at baseline assessment

• Be willing to be randomized to either trial arm (5-day or 7-day treatment)

• Able to complete trial procedures in the English language.

Exclusion Criteria:

• Have penicillin allergy

• Have bilateral cellulitis

• Have had antibiotics for cellulitis within the past month

• Have post-operative cellulitis (within 30 days of operative procedures on the same leg)

• Have cellulitis resulting from human/animal bite injury

• Have Cellulitis associated with chronic (>6 weeks) leg ulceration

• Require immediate hospital admission or out-patient intravenous antibiotic therapy