Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia

• Status: Unknown status
• Trial end date: 2020-12-30
• Target enrollment: 0
• Participant gender: All

Summary

A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Calgary

Criteria

Inclusion Criteria:

• Healthy adults

• 18 - 45 years of age

• Living in Calgary for the past one year

• Have no medical condition or should not be taking any blood pressure medications.

• The participant should not be lactose intolerant

Exclusion Criteria:

• Cerebrovascular, cardio-respiratory, renal and metabolic diseases

• Bleeding disorders and upper gastrointestinal diseases e.g. peptic ulcer disease

• Pregnancy, obese and sleep-disordered breathing

• Drug allergies to non-steroidal anti-inflammatories

• Currently smoking