Cerebral Flow-metabolism Coupling During Adult Surgery
Status:
Recruiting
Trial end date:
2025-12-31
Target enrollment:
Participant gender:
Summary
The brain is a highly active organ that requires a large blood flow to function properly.
Normally, blood flow is tightly linked to the brain's energy demands. However, during
surgery, anesthesia can affect this relationship in different ways. Some types of anesthesia
can decrease blood flow to the brain, while others can increase it. Anesthesiologists need to
be careful to maintain adequate blood flow to the brain during surgery, especially when blood
pressure drops. Drugs may be used to increase blood pressure, but some of these drugs can
also affect blood flow to the brain. It is still unclear how to best maintain blood flow to
the brain during surgery and how different types of anesthesia and drugs affect this process.
The study aims to assess the clinical utility of a new technique that uses light-based
neuromonitoring to measure changes in cerebral blood flow and metabolism. The investigators
will recruit 80 adult patients undergoing surgery under general anesthesia and randomize them
into one of four groups to evaluate the effects of different anesthetic agents and
vasopressors on brain hemodynamics and metabolism. The study will include patients over 18
years of age with no history of neurological conditions, substance abuse, or
contraindications to cerebral oximetry devices or specific anesthetic agents. The patients
will receive standard anesthesia care and be monitored with our light-based neuromonitoring
system. This study aims to demonstrate the device's ability to detect changes in cerebral
hemodynamic parameters related to anesthesia induction and systemic hypotension. This study
will also evaluate the effects of anesthetic maintenance agents and vasopressors on cerebral
hemodynamics and neurovascular coupling.