Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients

• Status: Terminated
• Trial end date: 2006-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a clinical study comparing the physiologic effects of two hypertonic solutions (mannitol, hypertonic saline) with a particular emphasis on changes in cerebral blood flow in patients with intracranial hypertension following serious traumatic brain injury (TBI).

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center at San Antonio
• Treatments: Mannitol

Criteria

Inclusion Criteria:

• Patients with severe TBI (motor Glasgow Coma Scale [GCS] score < 5)

• Age > 18 years

• Health care provider indicated a treatment of intracranial hypertension using hyperosmotic agent

Exclusion Criteria:

• Brain dead (GCS 3, fixed dilated pupils)

• Life-threatening systemic injuries (AIS > 4 in an organ system other than brain); AIS = Abbreviated Injury Score

• Hypotension not responsive to fluid resuscitation and low doses of dopamine

• Clinical or imaging sign/suspicion for internal carotid artery injury