Cerebral Perfusion Pressure Using Precedex and Other Sedatives

• Status: Completed
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the effects of using dexmedetomidine (Precedex) in addition to the current standard-of-care for sedation.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Collaborators: Hospira, Inc.; Hospira, now a wholly owned subsidiary of Pfizer
• Treatments: Dexmedetomidine; Hypnotics and Sedatives

Criteria

Inclusion Criteria:

• Admitted to Duke University Neuro Critical Care Unit (NCCU)

• Adult (18 years of age or older)

• Expected Mechanical Ventilation for >48 hours with sedation

• Intraventricular catheter in situ

Exclusion Criteria:

• Hypersensitivity to study drugs

• Prisoners

• Moribund state or death expected within 24 hours

• Surgery planned within 24 hours of subject enrollment

• Receiving study drug, Precedex, prior to entering study