Cerebral Vascular Effects of Dexmedetomidine Versus Propofol Sedation in Intubated Mechanically Ventilated ICU Patients
Status:
Suspended
Trial end date:
2021-09-16
Target enrollment:
Participant gender:
Summary
Serial transcranial Doppler (TCD) exams in healthy volunteers and in animal models showed a
strong linear relationship between middle cerebral artery (MCA) flow velocity (FV) and
dexmedetomidine infusion. The concomitant elevation of pulsatility index (PI) indicates
vasoconstriction of the cerebral vasculature as the most profound underlying mechanism.