Cerebral and Peripheral Perfusion Pilot Study

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the hypothesis that in middle-aged, asymptomatic, adult children of persons with Alzheimer's disease (AD), atorvastatin therapy will beneficially affect mechanisms thought to contribute to AD risk by improving blood flow in the brain, improving cerebral perfusion, increasing brain activity patterns, and improving blood vessel function.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Wisconsin, Madison
• Collaborator: National Institute on Aging (NIA)
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• Adult (ages 40-65) children of parent with documented Alzheimer's disease

Exclusion Criteria:

• Current use of cholesterol lowering medication

• History of liver disease

• History of adverse reaction to statin medications

• Elevated lab values (CK and creatinine)

• Use of medications that counteract with atorvastatin

• History of dementia

• Currently pregnant

• Use of large quantities of grapefruit juice (more than 1 quart/day)

• Current involvement in another investigational drug study

• Contraindications to MRI