Cerebral and Spinal Protection of Xenon Post-conditioning in Patients Undergoing Aortic Dissection Repair
Status:
Unknown status
Trial end date:
2018-09-01
Target enrollment:
Participant gender:
Summary
With more and more people developing hypertension and atherosclerosis, the morbidity rate of
Acute Aortic Dissection（AAD） has been increasing. Emergency surgery is the main treatment for
Acute Aortic Dissection. However the secondary injury caused by reperfusion of spinal cord
could lead to Catastrophic complications,such as paraplegia, hemiplegia or even death. So
spinal protection is always the hot topic in clinical research.
Xenon is an ideal anesthetic gases with the following features,fast onset of action, stable
hemodynamics, clean and non-toxic.The animal researches have showed the protective effects of
xenon to alleviate the ischemia-reperfusion injury of the nervous system.Those clues suggest
that Xenon may have the potential protection of spinal cord in patients undergoing aortic
dissection repair.In order to clarify this hypothesis, the investigators designed this
randomized, controlled clinic trial to evaluate the protection of Xenon against spinal cord
ischemia-reperfusion injury and the potential mechanisms