Cervical Preparation With Mifepristone Prior to Osmotic Dilators

• Status: Terminated
• Trial end date: 2021-02-26
• Target enrollment: 0
• Participant gender: Female

Summary

The investigators plan to study the role of mifepristone prior to the placement of cervical osmotic dilators to evaluate if the medication helps increase the number of dilators. This may help improve safety of dilation and evacuation (D&E) procedures.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, Davis
• Collaborator: Society of Family Planning
• Treatments: Mifepristone

Criteria

Inclusion Criteria:

A. Age ≥18 years B. Gestational age to be 18 weeks 0 days through 23 weeks 6 days on procedure date C. Signed informed procedure consent for dilation and evacuation D. Willing to sign informed consent and follow study protocol

Exclusion Criteria:

A. Allergy or known intolerance to mifepristone

B. Known contraindication to mifepristone for cervical preparation prior to dilation and evacuation:

1. Chronic adrenal failure or insufficiency

2. Concurrent use of long-term corticosteroid therapy

3. Inherited porphyrias

C. Any condition that in the opinion of the investigator could impede study participation or collection of study data