Cervical Ripening Before Endometrial Biopsy in Abnormal Uterine Bleeding Using Sublingual Misoprostol
Status:
Unknown status
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
Abnormal uterine bleeding is common in Thai women. Fractional curettage is an diagnostic
procedure of this condition. Traditionally, fractional curettage is performed under local
anesthesia such as paracervical nerve block or intravenous meperidine.
Cervical dilatation using "metal cervical dilator" is a common method prior to perform
fractional curettage. However, complication from this procedure can be occurred frequently,
for example, uterine perforation, false tract formation and laceration of cervix.
Misoprostol is a prostaglandin E1 analogue which is commonly used in obstetrics and
gynecology. Misoprostol transforms cervical component causing cervical ripening. This is very
helpful for transcervical procedure because cervical dilatation is usually omitted. It can be
prescribed in many route and sublingual route is the most effectiveness. Moreover, WHO
supports the use of misoprostol in obstetrics and gynecology practice.
The hypothesis of this study is that "Misoprostol 200 micrograms sublingually is effective
for cervical ripening before performing fractional curettage in patients with abnormal
uterine bleeding" Double blind randomised controlled trial was performed using 26 patients in
each group.
Phase:
N/A
Details
Lead Sponsor:
Mahidol University
Treatments:
Misoprostol Pyridoxal Pyridoxine Vitamin B 6 Vitamin B Complex Vitamins