Cervical Ripening in Postmenopausal Women

• Status: Terminated
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Misoprostol (Cytotec) 200ug vaginally will be given to patients 12 hours and 2 hours pre-operatively (before surgery) for a total of 400ug to ripen, soften or relax the cervix for dilation (opening). This is to assist with the insertion of a hysteroscope (the surgical instrument) into the uterus for all operative hysteroscopic procedures requiring dilation above 5 mm.

Time required for cervical dilatation will be recorded. Start time will be when the smallest dilator is placed into the endocervical canal, and stop time recorded when the desired cervical dilation is achieved with the largest dilator. Depending on the procedure, desired dilation may range between 5-10mm. Time will serve as a surrogate for operative ease of dilatation.

The investigators will compare the two groups in terms of medication, resistance, dilation time and size, side effects and surgical complications.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St. Louis University
• Treatments: Misoprostol

Criteria

Inclusion Criteria:

• 45-80yrs of age

• Postmenopausal (amenorrhea for greater than 1 year)

• May or may not be using hormone replacement therapy

• Scheduled or to be scheduled for hysteroscopy/resectoscopy procedures

Exclusion Criteria:

• Pregnant

• Known Cancer

• Known hypersensitivity to prostaglandins.

• Those who are breastfeeding