Cetuximab and Combination Chemotherapy in Treating Patients With Advanced or Metastatic Colorectal Cancer

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving cetuximab together with combination chemotherapy may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving cetuximab together with combination chemotherapy works in treating patients with advanced or metastatic colorectal cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: ICO Paul Papin; Institut Cancerologie de l'Ouest
• Treatments: Calcium; Cetuximab; Fluorouracil; Irinotecan; Leucovorin; Levoleucovorin

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed colorectal cancer

• Advanced or metastatic disease

• Scheduled to receive first- or second-line therapy for metastatic disease

• No cerebral metastases or symptomatic or uncontrolled meningeal disease

PATIENT CHARACTERISTICS:

• WHO performance status 0-2

• ANC ≥ 2,000/mm^3

• Platelet count ≥ 100,000/mm^3

• Total bilirubin ≤ 2 times upper limit of normal (ULN)

• AST and ALT ≤ 3 times ULN

• Alkaline phosphatase ≤ 5 times ULN

• Not pregnant or nursing

• Fertile patients must use effective contraception

• No intestinal blockage

• No complete dihydropyrimidine dehydrogenase deficiency

• No chronic inflammatory disease of the colon

• No other cancer except for nonmelanoma skin cancer or curatively treated carcinoma of the cervix or breast

• No other severe condition, or condition that is likely to worsen, including any of the following:

• Unstable heart disease

• Myocardial infarction within the past 6 months

• Active uncontrolled infection

• No contraindication to atropine

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• Recovered from prior anticancer therapy

• More than 4 weeks since prior and no other concurrent investigational therapy

• Prior adjuvant chemotherapy allowed

• No prior fluorouracil or irinotecan hydrochloride

• No other concurrent anticancer therapy