Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy

• Status: Completed
• Trial end date: 2019-05-15
• Target enrollment: 0
• Participant gender: All

Summary

Investigate serial plasma samples of fibroblast growth factor 19 (FGF19) after oral stimulation with chenodeoxycholic acid in the same subjects before and after elective cholecystectomy

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zealand University Hospital
• Treatments: Bile Acids and Salts; Chenodeoxycholic Acid

Criteria

Inclusion Criteria:

• planned elective cholecystectomy

Exclusion Criteria:

• small bowel resection

• right sided hemicolectomy

• known chronic diarrheal disease (celiac disease, lactose malabsorption, Inflammatory bowel diseases, incl microscopic colitis)

• pregnancy

• wish for pregnancy within next three months

• allergy to eggs

• allergy to constituents in Xenbilox (capsules with chenodeoxycholic acid)

• acute cholecystitis within two months

• chronic cholecystitis

• cirrhosis of the liver

• suspected obstructive choledocholithiasis

• icterus