Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in COPD Patients
Status:
Completed
Trial end date:
2011-07-01
Target enrollment:
Participant gender:
Summary
Respiration failure type 2 is loss of the lungs ability to take up oxygen (O2) and get rid of
carbon dioxide (CO2). The diagnosis is based on blood gas measurement of pressures of O2 and
CO2. Patients with COPD is often seen to have co-morbidity with cardiac diseases. Chronic
systemic inflammation is seen in both COPD and cardiac diseases. The investigators will
investigate the sleep quality, CO2-retention, O2-saturation, cardiac arrythmias and markers
of inflammation in 120 patients with COPD in different stages of the disease. Our hypotheses
are:
- that the first signs of respiration failure type 2 is seen during sleep with alteration
of sleep patterns and greater and more long-lasting retention of CO2 in the blood
compared to those with a normal lung function
- that the use of alcohol, zopiclone or supplementary oxygen will make these differences
even greater
- that cardiac arrythmias correlates with hypoxemia
- that cardiac arrythmias and respiration failure correlates with degree of inflammation
Phase:
N/A
Details
Lead Sponsor:
LHL Helse
Collaborators:
Haukeland University Hospital Landsforeningen for hjerte og lungesyke (LHL) ResMed Stiftelsen Helse og Rehabilitering University Hospital, Akershus