Changes in Dopamine Levels Before and After Weight Restoration in People With Anorexia Nervosa

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will use positron emission tomography imaging to investigate changes in dopamine systems in people with anorexia nervosa before and after weight restoration.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: New York State Psychiatric Institute
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Dopamine; Dopamine Agents; Methylphenidate; Raclopride

Criteria

Inclusion Criteria:

Participants with AN:

• Meets DSM-IV criteria for AN or ED-NOS (meets criteria for AN except amenorrhea)

• Sufficiently medically and psychiatrically stable to leave inpatient unit, as assessed by clinical team

Healthy control participants:

• No current or past psychiatric illness

• Between 80% and 120% of ideal body weight

Exclusion Criteria:

All participants:

• Current use of psychotropic medication such as antipsychotics or antidepressants

• Pregnant or breastfeeding

• History of a substance use disorder

• Significant medical illness

• High blood pressure (resting systolic blood pressure greater than 140 mmHg and diastolic blood pressure greater than 90 mmHg)

• Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV-TR

• Metal implants or paramagnetic objects contained within the body that may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to specified reference book guidelines

• Exposed to radiation in the workplace or has had a nuclear medicine procedure during the 1 year before study entry

• Previous adverse reaction to psychostimulants