Changes in Measured Plasma Volume, Glycocalyx and Atrial Natriuretic Peptide During Anaesthesia

• Status: Completed
• Trial end date: 2019-08-20
• Target enrollment: 0
• Participant gender: All

Summary

The arterial blood pressure is thought to affect the ratio between filtration and reabsorption of fluids in the circulating blood volume and thereby the plasma volume. During induction of anesthesia blood pressure, hemoglobin level and hematocrits decreases and the plasma volume increases. The aim of the study is to evaluate weather a maintained blood pressure with norepinephrine during anesthesia induction reduces the increase in 125 iodine-labeled human serum albumine (125I-HSA) measured plasma volume.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sahlgrenska University Hospital, Sweden
• Treatments: Anesthetics; Norepinephrine; Vasoconstrictor Agents

Criteria

Inclusion Criteria:

• Elective coronary artery surgery patients

Exclusion Criteria:

• Age under 40 years

• Untreated hypertension

• A reduced left ventricular systolic ejection fraction of 45% or less

• Diabetes mellitus

• Former stroke and/or a known carotid artery stenosis