Changes in Specific Immunoglobulin and Blood Basophil Activity During Subcutaneous Immunotherapy in Allergic Rhinitis
Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
The trial is randomized prospective study to examine the effects of subcutaneous
immunotherapy on the adaptive immune system. The trial includes 30 participants randomized to
treatment or control group. The effect measures are changes in the basophil activity and
biology as well as changes in plasma cells during and after treatment. Clinical outcome is
assessed by QoL questionnaires and clinical testing.
Hypotheses:
- changes in plasma cells correlate to changes in immunoglobulins and effector cell
responses
- the reduction of inflammation due to SCIT has influence on the effector cell responses
- changes in paraclinical measurements can be related to clinical findings
Phase:
N/A
Details
Lead Sponsor:
Aarhus University Hospital
Collaborators:
ALK-Abelló A/S Lundbeck Foundation University of Aarhus