Changes of Cerebral Glucose Metabolism After 12 Weeks of Paroxetine Treatment in Panic Disorder
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
Panic disorder is one of the most prevalent and disabling psychiatric disorders. Brain
regions such as amygdala, hippocampus, periaqueductal gray (PAG), locus coeruleus,
parahippocampal gyrus, frontal cortex, and thalamus has been reported to be related with the
pathophysiology and treatment outcome in panic disorder. Paroxetine has been used as primary
agent for treatment of panic disorder but there is little information on how paroxetine
affects the brain function in patients with panic disorder.
The specific aim of this study is to examine the differences in brain activity between
responders and nonresponders and to determine the predictor of paroxetine treatment in
patients with panic disorder in terms of brain activity.