Characterisation of the Human Carboxylesterase 1 (CES1) Mutations in Thailand

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to evaluate the conversion of OP to OC in individual X and the family member of individual X. The investigators hypothesize that one or more of the single nucleoprotein polymorphisms (SNPs) of the CES1 gene represent a clinically important functional polymorphism.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oxford
• Collaborator: South East Asia Infectious Disease Clinical Research Network
• Treatments: Oseltamivir

Criteria

Inclusion Criteria:

• Signed informed consent

• Healthy family member of individual X and individual X

• Aged between 18 and 70, inclusive.

Exclusion Criteria:

• known allergy to oseltamivir

• any underlying illness that is considered a risk to the health of the individual

• pregnant

• breast feeding

• creatinine clearance < 30 mL/min calculated by the Cockcroft Gault formula: CrCl (ml/min) = (140-age) x Wt in kg / creatinine mg/dL x 72, for females, the result is multiplied by 0.85.