Characterize The Modulatory Effects Of Dopamine D2/D3 Receptor Agonist And Antagonist Drugs On Compulsive Behaviors
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
3 groups of subjects (healthy controls, OCD subjects and stimulant-dependent subjects) will
receive pramipexole (1.5 mg, single dose), amisulpride (400 mg, single dose) or placebo in a
cross-over, double-blind, placebo-controlled design.
Effects of compulsive behaviour will be assessed using fMRI and cognitive testing.
Assess biomarkers including cardiovascular responses and plasma levels. All groups studied on
3 separate occasions following screening, with at least a week intervening between
consecutive assessments. The procedures to be adopted for study assessment will be identical
on each occasion.