Colorectal neoplasia is the second most common cancer in the United States and other Western
countries with about 140,000 newly diagnosed cases per year in the United States with a
mortality rate of about 40%. The identification of a specific natural or synthetic compound
with the ability to reverse or suppress the process of colon carcinogenesis would have
profound implication in the development of colorectal adenomas and their subsequent
transformation to colon cancer. Furthermore, the establishment of a correlative relationship
between biomarkers of cell proliferation, differentiation, apoptosis and adenoma recurrence
would provide pivotal data required to elucidate cell signaling mechanisms in future colon
cancer chemoprevention trials.
Phase:
Phase 2
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development