Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer
Status:
Active, not recruiting
Trial end date:
2022-05-10
Target enrollment:
Participant gender:
Summary
This phase II trial studies how well giving chemotherapy before surgery works in treating
patients with aggressive upper urinary tract cancer. Drugs used in chemotherapy, such as
methotrexate, vinblastine, doxorubicin hydrochloride, cisplatin, gemcitabine hydrochloride,
and carboplatin, work in different ways to stop the growth of tumor cells, either by killing
the cells, by stopping them from dividing, or by stopping them from spreading. Removing the
affected upper urinary tract by surgery is the recommended treatment for upper urinary tract
cancer, but can cause loss of kidney function and prevent patients from being able to receive
chemotherapy after surgery. Giving chemotherapy before surgery, when the kidneys are working
at their maximum, may allow less tissue to be removed during surgery and may be more
effective in treating patients with high grade upper urinary tract cancer.