Overview

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Giving more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving intrathecal and systemic combination chemotherapy together with radiation therapy works in treating young patients with newly diagnosed central nervous system (CNS) atypical teratoid/rhabdoid tumors.
Phase:
Phase 2
Details
Lead Sponsor:
Dana-Farber Cancer Institute
Collaborator:
National Cancer Institute (NCI)
Treatments:
Calcium
Calcium, Dietary
Cisplatin
Cortisol succinate
Cyclophosphamide
Cytarabine
Dactinomycin
Dexrazoxane
Doxorubicin
Etoposide
Hydrocortisone
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Hydrocortisone hemisuccinate
Lenograstim
Leucovorin
Levoleucovorin
Liposomal doxorubicin
Methotrexate
Razoxane
Temozolomide
Vincristine