Overview

Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: This phase II trial is studying how well chemotherapy followed by surgery and radiation therapy with or without stem cell transplant work in treating patients with relapsed or refractory Wilms' tumor or clear cell sarcoma of the kidney.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Children's Cancer and Leukaemia Group
Treatments:
Carboplatin
Cyclophosphamide
Dactinomycin
Doxorubicin
Etoposide
Liposomal doxorubicin
Melphalan
Vincristine
Criteria
DISEASE CHARACTERISTICS:

- Diagnosis of Wilms' tumor or clear cell sarcoma of the kidney, meeting 1 of the
following criteria:

- First relapse

- Refractory (progression during first-line therapy)

- Patients in second and subsequent relapses allowed if previously treated with
vincristine, dactinomycin, and doxorubicin combination chemotherapy (VCR/DACT/DOX)

- Metachronous tumors in the contralateral kidney allowed if previously treated with
VCR/DACT/DOX

- No rhabdoid tumor of the kidney

- Previously treated on UK Wilms' tumor study

PATIENT CHARACTERISTICS:

Age:

- Under 18

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- See Disease Characteristics

Endocrine therapy

- Not specified

Radiotherapy

- Not specified

Surgery

- Not specified

Other

- See Disease Characteristics