Overview

Chemotherapy, Radiation Therapy, Immunotherapy, and Bone Marrow Transplantation in Treating Patients With Neuroblastoma

Status:
Completed
Trial end date:
2004-09-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Radiation therapy uses high-energy x-rays to damage tumor cells. Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. PURPOSE: Phase II trial to study the effectiveness of combining chemotherapy, radiation therapy, immunotherapy, and bone marrow transplantation in treating patients with neuroblastoma.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Treatments:
Antibodies
Antibodies, Monoclonal
Cobalt
Cyclophosphamide
Doxorubicin
Etoposide
Immunoglobulins
Liposomal doxorubicin
Vincristine
Criteria
DISEASE CHARACTERISTICS: Neuroblastoma diagnosed in accordance with the International
Neuroblastoma Staging system: Histologic confirmation at MSKCC OR Elevated urinary
catecholamines plus tumor cells/clumps in bone marrow Stage IV or Stage II/III with more
than 10 copies of N-myc proto-oncogene per tumor cell

PATIENT CHARACTERISTICS: See General Eligibility Criteria

PRIOR CONCURRENT THERAPY: Prior therapy allowed -Patient Characteristics-- Age: Over 1 year
at diagnosis Performance status: Not specified Hematopoietic: Absolute neutrophil count at
least 500/mm3 (except for cases of bone marrow infiltration by tumor) Platelet count at
least 100,000/mm3 (except for cases of bone marrow infiltration by tumor) Hepatic: Not
specified Renal: Not specified Other: No history of allergy to mouse proteins Human
antimouse antibodies (HAMA) less than 1,000 U/ml (with prior exposure to murine antibodies)