Chemotherapy, Vaccine Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Multiple Myeloma

• Status: Completed
• Trial end date: 0000-00-00
• Target enrollment: 0
• Participant gender: Both

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Vaccines made from a person's cancer cells may make the body build an immune response to kill cancer cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy. Combining chemotherapy with vaccine therapy and peripheral stem cell transplantation may be effective in treating multiple myeloma.

PURPOSE: Phase I/II trial to study the effectiveness of chemotherapy followed by vaccine therapy and peripheral stem cell transplantation in treating patients who have newly diagnosed multiple myeloma.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Vaccines
• Last Updated: 2014-05-01

Criteria

DISEASE CHARACTERISTICS:

• Newly diagnosed multiple myeloma

• More than 30% bone marrow involvement

• Eligible for autologous peripheral blood stem cell transplantation

PATIENT CHARACTERISTICS:

Age:

• 18 to 70

Performance status:

• ECOG 0-2

Life expectancy:

• Not specified

Hematopoietic:

• Absolute neutrophil count greater than 500/mm^3

• Platelet count greater than 30,000/mm^3

Hepatic:

• Bilirubin less than 3 times normal

• AST/ALT less than 3 times normal

Renal:

• Not specified

Other:

• Not pregnant

• HIV negative

• No prior or active autoimmune disease

• No other prior malignancy within the past 5 years

• No major active medical or psychosocial problems

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• See Disease Characteristics

Chemotherapy:

• No more than 1 prior course of chemotherapy

Endocrine therapy:

• Not specified

Radiotherapy:

• Concurrent local radiotherapy allowed

Surgery:

• Not specified