Chemotherapy With or Without Surgical Resection in Locally Advanced Esophageal Cancer
Status:
Completed
Trial end date:
2007-07-01
Target enrollment:
Participant gender:
Summary
In this randomized study, we plan to address the important question of optimum local
treatment for patients with localized esophageal cancer. All patients will receive our
previously studied neo-adjuvant regimen including paclitaxel, carboplatin, infusional 5-FU,
and radiation therapy to 45 Gy. At the completion of neo-adjuvant therapy, patients will be
randomized to undergo surgical resection, or to continue radiation to a total dose of 60 Gy,
along with one additional course of chemotherapy.