Chemotherapy and Radiation Therapy in Treating Patients With HIV-Related Primary Central Nervous System Lymphoma

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving methotrexate and zidovudine together with radiation therapy works in treating patients with HIV-related primary central nervous system lymphoma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centro di Riferimento Oncologico - Aviano
• Treatments: Methotrexate; Zidovudine

Criteria

DISEASE CHARACTERISTICS:

• Histologically proven HIV-related non-Hodgkin's lymphoma of the CNS

• No systemic lymphoma

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• WHO 0-3

Life expectancy:

• Not specified

Hematopoietic:

• WBC at least 3000/mm^3

• Platelet count at least 80,000/mm^3

Hepatic:

• No serious impairment of liver function

Renal:

• No serious impairment of renal function

• Creatinine clearance at least 40 mL/min

Cardiovascular:

• No serious impairment of cardiac function

Neurologic:

• Neurological functional status 0-3

Other:

• No prior or active CNS-opportunistic infections

• No AIDS dementia complex

• No active systemic infections

PRIOR CONCURRENT THERAPY:

• No prior chemotherapy or radiotherapy