Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of chemotherapy and radiation therapy in treating patients who have stomach cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radiation Therapy Oncology Group
• Collaborator: National Cancer Institute (NCI)
• Treatments: Calcium; Fluorouracil; Leucovorin; Levoleucovorin; Paclitaxel

Criteria

DISEASE CHARACTERISTICS:

• Histologically proven adenocarcinoma of the stomach

• Stage IB, II, IIIA, IIIB, and IV (T2-3, any N, M0)

• No lymph node metastases outside the field of resection (e.g., supraclavicular, mediastinal, or paraaortic nodes)

• Potentially resectable

• May involve the gastroesophageal junction, but bulk of tumor must be in the stomach

• No distant metastases

• No pleural or pericardial effusion

• No peritoneal disease diagnosed by laparoscopy

PATIENT CHARACTERISTICS:

Age:

• Not specified

Performance status:

• Zubrod 0-2

Life expectancy:

• At least 16 weeks

Hematopoietic:

• Absolute granulocyte count greater than 2,000/mm^3

• Platelet count greater than 100,000/mm^3

Hepatic:

• Bilirubin no greater than 1.5 mg/dL

Renal:

• Creatinine less than 1.5 mg/dL

Cardiovascular:

• No New York Heart Association class III or IV heart disease

• No hypertension

Neurologic:

• No cerebrovascular disease

• No diabetic neuropathy

• No mental status abnormalities

Other:

• No uncontrolled diabetes

• No infection

• No other malignancies within past 5 years except resected squamous cell or basal cell skin cancer

• Not pregnant or nursing

• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• No prior immunotherapy

Chemotherapy:

• No prior chemotherapy

Endocrine therapy:

• Not specified

Radiotherapy:

• No prior radiotherapy to stomach

Surgery:

• No prior surgery to stomach