Chemotherapy in Treating Patients With Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor

• Status: Terminated
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have metastatic Ewing's sarcoma or primitive neuroectodermal tumor.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
• Treatments: Cisplatin; Etoposide; Etoposide phosphate

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed Ewing's family tumor as characterized by the following:

• Positive MIC2 on immunohistochemistry OR

• Evidence of a chromosomal translocation involving the EWS gene by conventional cytogenetics

• t(11; 22) translocation or variant OR

• Demonstration of EWS/FLI1 or EWS/ERG gene fusion by PCR or FISH

• Metastases outside the lung or pleura

• At least 1 measurable lesion outside of previously irradiated area

• No symptomatic or known CNS metastases

PATIENT CHARACTERISTICS:

Age:

• 15 to 65

Performance status:

• WHO 0-2

Life expectancy:

• Not specified

Hematopoietic:

• WBC at least 3,000/mm3

• Neutrophil count at least 2,000/mm3

• Platelet count at least 100,000/mm3

Hepatic:

• Bilirubin less than 3 mg/dL

• Albumin greater than 2.5 g/dL

Renal:

• Creatinine less than 1.2 mg/dL

• Creatinine clearance greater than 70 mL/min

Cardiovascular:

• No history of uncontrolled cardiovascular disease

Other:

• No other severe medical illness, including psychosis

• No other prior primary malignancy except adequately treated carcinoma in situ of the cervix or basal cell skin cancer

• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior chemotherapy

Endocrine therapy:

• Not specified

Radiotherapy:

• See Disease Characteristics

Surgery:

• Not specified