Stage 5 chronic kidney disease (CKD), also end stage renal disease(ESRD), usually presents
overt clinical symptoms and is a critical stage when patients are encountered with dialysis.
The optimal time to initiating dialysis in patients with stage 5 CKD is addressed as the most
important dialysis-related question. As indicated by the recently published European Renal
Best Practice (ERBP) guideline, early initiation seemed to produce no benefit but greater
expenditure and sometimes more harm.Renal replacement therapies (RRT) including dialysis are
the most common procedures for patients with end-stage renal disease (ESRD), but conservative
management should be an option in patients who still experience the stable period without
clinical indications of dialysis.Chinese Medicine (CM) is recognized as an alternative
therapy on alleviating uremic symptoms, deferring dialysis initiation, and improving quality
of life. Although the effects of CM on kidney disease have been demonstrated in animal
experiments, evidence from large clinical trial is insufficient. So we raise the hypothesis
that CM therapies including Chinese herbal formula, Chinese patent medicine via oral pattern
and/or Colonic administration, will defer the initiation of dialysis in adults with stage 5
CKD.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Guangdong Provincial Hospital of Traditional Chinese Medicine
Collaborator:
Ministry of Science and Technology of the People´s Republic of China