Overview
Chloroquine and Coartem for Treatment of Symptomatic Children With Plasmodium Falciparum in Guinea Bissau
Status:
Completed
Completed
Trial end date:
2008-11-01
2008-11-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
This study will evaluate the efficacy of treatment with artemether-lumefantrine as compared to chloroquine in the dose of 50 mg/kg for treatment of malaria in children in Guinea-Bissau. The genetic basis of the parasites for developing resistance will be examined. Children coming to one of the Health Centres with symptoms of malaria and a positive malaria test will be included. The children will be followed weekly until day 70. In case of reappearance of parasites the child will be re-treated with the opposite study drug.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Bandim Health ProjectTreatments:
ArtemetherArtemether-lumefantrine combination
Artemether, Lumefantrine Drug Combination
Artemisinins
Chloroquine
Chloroquine diphosphate
Lumefantrine
Criteria
Inclusion Criteria:- Children presenting at one of the health centres in the study area
- Symptoms suggestive of malaria
- At least 20 P.falciparum parasites per 200 leucocytes
- Living in the study area (to enable follow-up)
Exclusion Criteria:
- Danger signs
- By the responsible doctor evaluated to need to be transferred to the national hospital
as an in-patient
- Previous idiosyncratic reactions to any of the study drugs