Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function

• Status: Withdrawn
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Chlorthalidone will result in improved endothelial function compared to hydrochlorothiazide as measured by flow mediated vasodilatation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Creighton University
• Treatments: Chlorthalidone; Hydrochlorothiazide

Criteria

Inclusion Criteria:

• Age 19 or older

• Diagnosis of hypertension

• Current blood pressure > 120/80 mm Hg

Exclusion Criteria:

• Use of a thiazide-type diuretic within the last 1 month

• Known allergy to any study medications

• History of gout or hyperuricemia

• SCr >/= 1.8 mg/dl or CrCl < 25 ml/min

• Pregnancy or breastfeeding or planning to become pregnant during study period

• Dementia or cognitive impairment

• Hypokalemia

• Acute coronary syndrome or stroke within 6 months

• Current use of sildenafil, tadalafil, or vardenafil