Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency.
Status:
Terminated
Trial end date:
2019-11-09
Target enrollment:
Participant gender:
Summary
The purpose of the research study is to determine whether a single high dose of vitamin D is
helpful in reducing critical illness related complications in intensive care patients who are
having sever vitamin D deficiency.
Vitamin D deficiency is quite common in critically ill patients ranging from 81.5% to 99%. A
number of scientific studies have documented a strong correlation between low levels of vit.D
and increased rate of adverse outcomes including infection, acute kidney injury and mortality
in ICU patients. A recent randomized controlled trial (RCT) has demonstrated a 50% reduction
in hospital mortality in severe vit.D deficient patients following a single high dose of
cholecalciferol (Vitamin D3). However, the role of Vit.D supplementation to boost up host
immune system and eventually reduction of mortality has yet to be determined by large
randomized controlled trials in humans. Hence the study aims to run a randomized controlled
trial (RCT) in order to study the role of Vitamin D in critically ill patients.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
King Abdullah Medical City
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins