Cholinergic Neurotransmission in Mobility and Cognition in Parkinson Disease

• Status: Completed
• Trial end date: 2020-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a single-site non-randomized open label pilot study. The investigators will use accelerometer-based instrumented gait analysis and computerized cognitive testing to study the interaction of motor and cognitive dysfunction in Parkinson disease dementia (PDD), and the effect of rivastigmine on motor and cognitive performance. All study participants will tested for motor and cognitive performance at baseline (arm 1). A subgroup of study participants will then be treated with rivastigmine for 12 weeks (arm 2), and the effect of this treatment on gait measures and cognitive measures will be analyzed at the follow-up visit 12 weeks after the baseline visit. Specifically, we will determine which components of motor and cognitive impairment are associated with each other, and which components of the two domains respond to rivastigmine-mediated stimulation of cholinergic neurotransmission.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Maryland; University of Maryland, Baltimore
• Collaborator: National Institute on Aging (NIA)
• Treatments: Cholinergic Agents; Rivastigmine

Criteria

Inclusion Criteria:

• Age ≥ 18 years.

• Diagnosis of idiopathic Parkinson disease.

• Mild to moderate cognitive impairment, as determined by a MoCA score of ≤ 25 and ≥ 10.

• Patient passes the Evaluation to Sign Consent (ESC) or a legally authorized representative (LAR) is present at the time of enrollment and signs the informed consent form on behalf of the patient.

• Patient is enrolled (or willing to be enrolled) in the University of Maryland Parkinson Disease and Movement Disorders Center PD Research Database (HP 42195)

Exclusion Criteria:

• Advanced Parkinson disease (Hoehn & Yahr stage 5), with inability to walk unassisted.

• Other medical condition(s) that significantly interfere(s) with gait and balance (e.g., advanced arthritis).