Chronic Beta2-adrenergic Stimulation and Cardiac and Skeletal Muscle Hypertrophy

• Status: Completed
• Trial end date: 2015-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

Studies in animals have shown that beta2-adrenoceptor activation with selective agonists regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue. These effects may be mediated by cAMP/PKA dependent activation of several downstream sites that modulate protein synthesis and breakdown. While the role of beta2-adrenoceptor signaling is well-described in animals, it is inadequately explored in humans. The purpose of the study is thus to investigate the effect of chronic beta2-adrenergic stimulation (cAMP/PKA-signaling) on muscle hypertrophy.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Copenhagen
• Collaborators: Bispebjerg Hospital; University of Southern Denmark
• Treatments: Adrenergic Agents; Albuterol

Criteria

Inclusion Criteria:

• Physical active

• Non-smokers

• Non-asthmatics

• No chronic diseases

• Informed consent

Exclusion Criteria:

• Smoker

• Allergy towards study drug