Chronic Beta2-adrenergic Stimulation and Cardiac and Skeletal Muscle Hypertrophy
Status:
Completed
Trial end date:
2015-11-01
Target enrollment:
Participant gender:
Summary
Studies in animals have shown that beta2-adrenoceptor activation with selective agonists
regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue. These
effects may be mediated by cAMP/PKA dependent activation of several downstream sites that
modulate protein synthesis and breakdown. While the role of beta2-adrenoceptor signaling is
well-described in animals, it is inadequately explored in humans. The purpose of the study is
thus to investigate the effect of chronic beta2-adrenergic stimulation (cAMP/PKA-signaling)
on muscle hypertrophy.
Phase:
N/A
Details
Lead Sponsor:
University of Copenhagen
Collaborators:
Bispebjerg Hospital University of Southern Denmark