Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
Status:
Recruiting
Trial end date:
2025-06-30
Target enrollment:
Participant gender:
Summary
The CHAP2 study is designed to provide preliminary data for a larger multicenter study to
assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or
neonatal outcomes. The primary objective of this pilot study is to determine if anti-HTN
treatment to BP<130/80mmHg in pregnant patients with stage 1 HTN is associated with a
difference in birthweight percentile at delivery. Patients with stage 1 hypertension in
pregnancy will be randomized to BP goals of <130/80mmHg or usual care to treatment only if
BPs ≥140/90mmHg. For this pilot, the investigator will randomize a total of 74 eligible
participants, 37 to active treatment to BP<130/80mmHg and 37 to usual care.