This is a randomized double-blinded placebo-controlled trial to see if treatment with
sertraline as compared with placebo tablets will improve depression symptoms in patients with
chronic kidney disease who have not yet started dialysis or received a kidney transplant. The
investigators will also investigate whether sertraline treatment will improve quality of life
and whether it is safe to use in patients with kidney disease. The study subject will be
randomly assigned to take either sertraline or a placebo tablet for 12 weeks.
Phase:
Phase 3
Details
Lead Sponsor:
VA Office of Research and Development
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) University of Texas Southwestern Medical Center