Chronic Non-bacterial Osteomyelitis Treated With Pamidronate
Status:
Unknown status
Trial end date:
2018-08-01
Target enrollment:
Participant gender:
Summary
In a randomized double blind placebo controlled trial to investigate the effect of
pamidronate in treatment of chronic non bacterial osteomyelitis.
Main objective:
1. Reduction of the inflammatory activity in the bone lesions measured by whole body MRI
after 36 weeks.
2. Healing of the inflammatory activity in the bone lesions measured by whole body MRI
after 36 weeks.
Secondary objectives:
1. Changes in bone lesions in whole body MRI between baseline and week 12 and between week
12 and week 36
2. Changes in bone lesions of anterior chest-wall (adults) evaluated by CT scan between
baseline and week 36.
3. Changes in patient self reported outcome measures
4. Changes in inflammatory markers and bone markers.