Chronic Pain and Vitamin D

• Status: Unknown status
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Non-systematized chronic musculoskeletal pains are a frequent reason for consulting in general practice. The possible causes are numerous and sometimes nonspecific. In some cases, the etiologic investigation of patients with non-systematized and chronic musculoskeletal pain can not highlight any organic cause. Several studies have shown a link between these symptoms and vitamin D deficiency, characterized by a blood level of 25 (OH) vitamin D < 20.8ng/ml. This deficit is easy to identify and to correct through proper vitamin D supplementation with few side effects. Nevertheless, it remains unknown and vitamin D deficiency is rarely considered as a possible etiology in patients with chronic pain. We hypothesize that vitamin D supplementation in patients with non-systematized musculoskeletal pain and deficient in vitamin D could improve painful symptoms. We aim to perform a double-blind randomized controlled trial, vitamin D versus placebo, to assess the pain improvement after vitamin D supplementation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospices Civils de Lyon
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Women and men

• Aged 18-50 years (included)

• Consulting their general practitioner

• With chronic and diffuse musculoskeletal pain, without known etiology, lasting for at least 3 months

• With a 25(OH)vitamin D deficiency <20.8 ng/ml (52 nmol/l) at inclusion

• Who signed the consent form

Exclusion Criteria:

• Identifiable source of pain requiring an appropriate specific management

• Disease or treatment that may interfere with the metabolism of vitamin D

• Current or previous hypercalcemia or hypercalciuria, treatment with digitalics and patients with history of nephrolithiasis

• Current treatment with vitamin D or at least one vitamin D vial taken over the previous 6 months

• Pregnancy or breastfeeding

• not affiliated to a social security system

• Refusal or inability to give consent