Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study

• Status: Withdrawn
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This is a study to evaluate the cause of chronic sinus disease. Oral steroids have long been used in the treatment of inflammatory conditions including chronic sinusitis, asthma, and arthritis. However, it is not well known exactly which patients will benefit from steroids when used in the treatment of chronic sinusitis. For some doctors, it is common practice to use these medications prior to planned sinus surgery, to lessen the inflammation and possibly help the healing process. Other doctors feel oral steroids may not be helpful in this way, and there is no conclusive data as to whether this practice has a long term benefit.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Northwestern University
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Glucocorticoids; Prednisone

Criteria

Inclusion Criteria:

• Ages 18 years to 70 years

• Diagnosis of chronic rhinosinusitis (CRS) with nasal polyps (NP) and will be undergoing sinonasal surgery for this condition

• Diagnosis of CRS without NP and will be undergoing sinonasal surgery for this condition

• No diagnosis of CRS and NP and will be undergoing nasal surgery (septoplasty/rhinoplasty, nasal fracture repair,etc.)

Exclusion Criteria:

• Ages younger than 18 years and ages older than 70 years

• Diagnosis of an established immunodeficiency, pregnancy, coagulation disorder, a diagnosis of allergic fungal sinusitis (AFS), or cystic fibrosis

• Those with CRS with or without NP in whom systemic steroid therapy would be contraindicated

• Those who are dependent on systemic steroid therapy for sinonasal disease or any other condition