Chronic Subdural Hematoma - Reduction of Recurrence by Treatment With Angiotensin Converting Enzyme Inhibitors

• Status: Terminated
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The project aims at investigating if treatment with the Angiotensin Converting Enzyme inhibitor Coversyl (perindopril) for 3 months after surgery for chronic subdural hematoma will decrease the risc of recurrence.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Odense University Hospital
• Collaborators: Alice Brenaa Foundation; Hede Nielsen Foundation; Overlægerådets legatudvalg; University of Southern Denmark
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Enzyme Inhibitors; Perindopril

Criteria

Inclusion Criteria:

1. Patients with chronic subdural hematoma that needs surgical evacuation

2. Age > 18 year

Exclusion Criteria:

1. Lack of compliance

2. Kidney artery stenosis

3. Stenosis of the aorta

4. Severely decreased kidney function

5. Allergy or intolerance/contraindications toward ACE inhibitors

6. Already in ACE inhibitor treatment

7. Coagulopathies

8. Malignant disorders

9. Fertile women

10. Other neurological disorders

11. Treatment with pharmaceuticals contraindicating treatment with ACE inhibitors