Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer

• Status: Unknown status
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: All

Summary

1. Observe and compare the chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy term efficacy of the treatment of locally advanced nasopharyngeal carcinoma.

2. Evaluation chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy in locally advanced nasopharyngeal carcinoma safety and tolerability.

3）observing the adverse reaction and effects of two groups,expected chrono-chemotherapy group can achieve lower toxicity, improve the curative effect, for the treatment of nasopharyngeal carcinoma provides a more reasonable way.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guiyang Medical University
• Collaborators: Sun Yat-sen University; The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University
• Treatments: Cisplatin

Criteria

Inclusion Criteria:

• initial treatment of advanced nasopharyngeal carcinoma Ⅲ-Ⅳ patients with pathologically confirmed (according to 2010 UICC staging, T3-4, N0-3), without evidence of distant metastasis (M0). Have measurable tumor lesions.

• KPS≥70 points.

• the age of 18-70 years old, male or female.

• no major organ dysfunction; normal bone marrow function (WBC ≥4.0 × 109 / L, platelets ≥100 × 109 / L, hemoglobin ≥90g / L), normal liver function (total bilirubin, alanine aminotransferase, aspartate aminotransferase ≤1.5 times the upper limit of normal), normal renal function (creatinine ≤ 1.5 times upper limit of normal).

• understand this study and signed informed consent.

Exclusion Criteria:

• distant metastasis.

• who had received prior chemotherapy.

• patients have physical or mental illness, and by researchers believe that patients can not be completely or fully understood in this study possible complications.

• pregnancy (via the urine or serum β-HCG test confirmed) or during lactation.

• serious complications, such as uncontrolled hypertension, heart failure, diabetes and so on.