Chronos: the Use of Chronobiological Treatment in Depression
Status:
Completed
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
The primary objective of the present study is to examine whether the combination of the
antidepressant duloxetine and chronotherapeutic methods (including sleep deprivation, light
therapy, and maintaining a regular sleep-wake rhythm) in patient with major depression, will
induce an immediate improvement from depression and whether this antidepressive effect will
be maintained in the long term (29 weeks). Patient will be randomised to the above mentioned
treatment or to an active group receiving exercise.